Measuring mechanical function in the failing heart

Mechanical unloading increases caveolin expression in the failing human heart.

OBJECTIVE Implantation of a left ventricular assist device (LVAD) in the failing human heart initiates structural and functional changes termed reverse remodeling. Mechanical unloading improves cardiac adrenergic responsiveness and lipid metabolism, processes regulated by caveolar function. We tested the hypothesis that mechanical unloading alters the expression of caveolins and these changes a...

Cell transplantation to improve ventricular function in the failing heart.

Current therapies for congestive heart failure are limited in efficacy or in applicability. Cardiac cell transplantation offers a novel therapeutic approach to improve heart function. Although significant progress has been made over the past decade in the development of cell transplantation, only recently have investigators studied the changes in ventricular function following cell transplantat...

Measuring the quantum mechanical wave function

In the past few years experimenters have learned how to determine the complete quantum state of an ensemble of particles or ® elds which have been prepared according to some unknown procedure. Through these experiments they have answered a question posed by W. Pauli in the 1930s. The methods used involve measuring statistical distributions of a well chosen set of physical observables and using ...

Mechanical function of the septating embryonic heart.

Pharmacogenomics and the Failing Heart

n Samuel Beckett’s play, Waiting for Godot, the characters ait by a country roadside for a person named Godot, who ever arrives (1). Godot’s conspicuous absence throughout he play has fostered a variety of different religious, philoophical, and psychoanalytical interpretations, and has led o the use of the phrase “waiting for Godot” as an expression or waiting for someone or something that will...